EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes turmorigenesis

Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be defined. We demonstrate here that EGFR activation induces PLCγ1-dependent PKCε monoubiquitylation at Lys321 mediated by RINCK1 ubiquitin ligase...

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Detalhes bibliográficos
Main Authors: Yang, Weiwei, Xia, Yan, Cao, Yu, Zheng, Yanhua, Bu, Wen, Zhang, Lin, You, M. James, Koh, Mei Yee, Cote, Gilbert, Aldape, Kenneth, Li, Yi, Verma, Inder M., Chiao, Paul J, Lu, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526114/
https://ncbi.nlm.nih.gov/pubmed/23123196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.09.028
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