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Effects of Familial Mutations on the Monomer Structure of Aβ(42)
Amyloid beta (Aβ) peptide plays an important role in Alzheimer’s disease. A number of mutations in the Aβ sequence lead to familial Alzheimer’s disease, congophilic amyloid angiopathy, or hereditary cerebral hemorrhage with amyloid. Using molecular dynamics simulations of ∼200 μs for each system, we...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525840/ https://ncbi.nlm.nih.gov/pubmed/23260058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.009 |
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