How do CARs work?: Early insights from recent clinical studies targeting CD19

Second-generation chimeric antigen receptors (CARs) are powerful tools to redirect antigen-specific T cells independently of HLA-restriction. Recent clinical studies evaluating CD19-targeted T cells in patients with B-cell malignancies demonstrate the potency of CAR-engineered T cells. With results...

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Bibliographic Details
Main Authors: Davila, Marco L., Brentjens, Renier, Wang, Xiuyan, Rivière, Isabelle, Sadelain, Michel
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525612/
https://ncbi.nlm.nih.gov/pubmed/23264903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.22524
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