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Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase
Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity–onset diabetes of the young type II (MODY-II) and persistent hypogl...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525530/ https://ncbi.nlm.nih.gov/pubmed/23271955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001452 |
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