Screening chelating inhibitors of HIF-Prolyl Hydroxylase Domain 2 (PHD2) and Factor Inhibiting HIF (FIH)

Two primary O(2)-sensors for humans are the HIF-hydroxylases, enzymes that hydroxylate specific residues of the hypoxia inducible factor-α (HIF). These enzymes are factor inhibiting HIF (FIH) and prolyl hydroxylase-2 (PHD2), each an α-ketoglutarate (αKG) dependent, nonheme Fe(II) dioxygenase. Althou...

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Bibliographic Details
Main Authors: Flagg, Shannon C., Martin, Cristina B., Taabazuing, Cornelius Y., Holmes, Breanne E., Knapp, Michael J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525482/
https://ncbi.nlm.nih.gov/pubmed/22687491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2012.03.002
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