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Increased turnover under limiting [O(2)] by the Thr(387)→Ala variant of the HIF-prolyl hydroxylase PHD2
PHD2 is a 2-oxoglutarate, non-heme Fe(2+) dependent oxygenase that senses O(2) levels in human cells by hydroxylating two prolyl residues in the oxygen dependent degradation domain (ODD) of HIF1α. Identifying the active site contacts that determine the rate of reaction under limiting O(2) is crucial...
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| Publicat a: | Biochemistry |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4939847/ https://ncbi.nlm.nih.gov/pubmed/25857330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501540c |
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