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Inverse solvent isotope effects demonstrate slow aquo release from HIF-prolyl hydroxylase (PHD2)
Prolyl Hydroxylase Domain 2 (PHD2) is deemed a primary oxygen sensor in humans yet many details of its underlying mechanism are still not fully understood. (Fe(2+)+αKG)PHD2 is 6-coordinate, with a 2His/1Asp facial triad occupying 3 coordination sites, a bidentate α-ketoglutarate occupying two sites...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525350/ https://ncbi.nlm.nih.gov/pubmed/22747465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300229y |
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