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Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation
Cannabinoid 1 (CB1) receptors have been previously detected in pancreatic β cells, where they influence insulin action. We now report that CB1 receptors form a heteromeric complex with insulin receptors and Gα(i), which inhibits insulin receptor kinase activity in β cells by directly binding to the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3524575/ https://ncbi.nlm.nih.gov/pubmed/22434934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002519 |
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