Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells

OBJECTIVE: Optimal glucose homeostasis requires exquisitely precise adaptation of the number of insulin-secreting β-cells in the islets of Langerhans. Insulin itself positively regulates β-cell proliferation in an autocrine manner through the insulin receptor (IR) signaling pathway. It is now coming...

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Hlavní autoři: Kim, Wook, Doyle, Máire E., Liu, Zhuo, Lao, Qizong, Shin, Yu-Kyong, Carlson, Olga D., Kim, Hee Seung, Thomas, Sam, Napora, Joshua K., Lee, Eun Kyung, Moaddel, Ruin, Wang, Yan, Maudsley, Stuart, Martin, Bronwen, Kulkarni, Rohit N., Egan, Josephine M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064093/
https://ncbi.nlm.nih.gov/pubmed/21346174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1550
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