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Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation

Cannabinoid 1 (CB1) receptors have been previously detected in pancreatic β cells, where they influence insulin action. We now report that CB1 receptors form a heteromeric complex with insulin receptors and Gα(i), which inhibits insulin receptor kinase activity in β cells by directly binding to the...

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Bibliografiske detaljer
Main Authors: Kim, Wook, Lao, Qizong, Shin, Yu-Kyong, Carlson, Olga D., Lee, Eun Kyung, Gorospe, Myriam, Kulkarni, Rohit N., Egan, Josephine M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524575/
https://ncbi.nlm.nih.gov/pubmed/22434934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002519
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