Pharmacology of Cefaclor in Normal Volunteers and Patients with Renal Failure

After a 500-mg dose of cefaclor, the mean peak plasma level was 12.4 μg/ml and after a 250-mg dose it was 5 μg/ml in normal volunteers. Food intake significantly reduced absorption. Probenecid prolonged plasma levels. Mean plasma half-life in normal volunteers was 0.8 h. Only about 50% of the dose w...

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Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Antimicrob Agents Chemother
Prif Awduron:	Santoro, Jerome, Agarwal, B. N., Martinelli, Reinaldo, Wenger, Norma, Levison, Matthew E.
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology (ASM) 1978
Pynciau:	Pharmacology and Therapeutics
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352368/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/677862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.13.6.951
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