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Pharmacology of Cefaclor in Normal Volunteers and Patients with Renal Failure

After a 500-mg dose of cefaclor, the mean peak plasma level was 12.4 μg/ml and after a 250-mg dose it was 5 μg/ml in normal volunteers. Food intake significantly reduced absorption. Probenecid prolonged plasma levels. Mean plasma half-life in normal volunteers was 0.8 h. Only about 50% of the dose w...

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Autors principals: Santoro, Jerome, Agarwal, B. N., Martinelli, Reinaldo, Wenger, Norma, Levison, Matthew E.
Format: Artigo
Idioma:Inglês
Publicat: 1978
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC352368/
https://ncbi.nlm.nih.gov/pubmed/677862
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