Selective FLT3 inhibition of FLT3-ITD(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

Acquired resistance to selective FLT3 inhibitors, is an emerging clinical problem in the treatment of FLT3-ITD(+) acute myeloid leukaemia (AML). The paucity of valid pre-clinical models has limited investigations to determine the mechanism of acquired therapeutic resistance, thereby limiting the dev...

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Main Authors: Moore, Andrew S., Faisal, Amir, de Castro, David Gonzalez, Bavetsias, Vassilios, Sun, Chongbo, Atrash, Butrus, Valenti, Melanie, de Haven Brandon, Alexis, Avery, Sian, Mair, Debbie, Mirabella, Fabio, Swansbury, John, Pearson, Andrew D.J., Workman, Paul, Blagg, Julian, Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523391/
https://ncbi.nlm.nih.gov/pubmed/22354205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.52
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