Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736

Internal tandem duplication of FLT3 (FLT3-ITD) is one of the most common somatic mutations in acute myeloid leukemia (AML); it causes constitutive activation of FLT3 kinase and is associated with high relapse rates and poor survival. Small-molecule inhibition of FLT3 represents an attractive therape...

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Udgivet i:Blood Adv
Main Authors: Moore, Andrew S., Faisal, Amir, Mak, Grace W. Y., Miraki-Moud, Farideh, Bavetsias, Vassilios, Valenti, Melanie, Box, Gary, Hallsworth, Albert, de Haven Brandon, Alexis, Xavier, Cristina P. R., Stronge, Randal, Pearson, Andrew D. J., Blagg, Julian, Raynaud, Florence I., Chopra, Rajesh, Eccles, Suzanne A., Taussig, David C., Linardopoulos, Spiros
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160287/
https://ncbi.nlm.nih.gov/pubmed/32282883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000986
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