Metabolic Fate of [(14)C]Cefamandole, a Parenteral Cephalosporin Antibiotic, in Rats and Dogs

The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Sullivan, H. R., Due, S. L., Kau, D. L. K., Quay, J. F., Miller, W. M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1977
Soggetti:	Pharmacology and Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352156/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/883820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.12.1.73
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