Metabolic Fate of [(14)C]Cefamandole, a Parenteral Cephalosporin Antibiotic, in Rats and Dogs

The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both...

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Библиографические подробности

Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Sullivan, H. R., Due, S. L., Kau, D. L. K., Quay, J. F., Miller, W. M.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1977
Предметы:	Pharmacology and Therapeutics
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352156/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/883820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.12.1.73
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