Metabolic Fate of [(14)C]Cefamandole, a Parenteral Cephalosporin Antibiotic, in Rats and Dogs

The biotransformation of the parenterally effective cephalosporin antibiotic cefamandole nafate (I) has been studied in rats and dogs. After rapid in vivo hydrolysis of the nafate pharmaceutical form to cefamandole (II), the antibiotic was found to be very resistant to metabolic degradation in both...

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Publikašuvnnas:	Antimicrob Agents Chemother
Váldodahkkit:	Sullivan, H. R., Due, S. L., Kau, D. L. K., Quay, J. F., Miller, W. M.
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology (ASM) 1977
Fáttát:	Pharmacology and Therapeutics
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352156/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/883820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.12.1.73
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