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Antitussive effects of the peripherally restricted GABA(B) receptor agonist lesogaberan in guinea pigs: comparison to baclofen and other GABA(B) receptor-selective agonists

BACKGROUND: Gastroesophageal reflux disease (GERD) is a common cause of chronic cough. Both acid and nonacid reflux is thought to play a role in the initiation of coughing and cough hypersensitivity. The GABA(B) receptor agonist lesogaberan was developed as a peripherally restricted anti-reflux ther...

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Detalhes bibliográficos
Main Authors: Canning, Brendan J, Mori, Nanako, Lehmann, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520872/
https://ncbi.nlm.nih.gov/pubmed/23025757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-9974-8-7
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