TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis

BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4(+) T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells most efficiently is the dendritic cell (DC). As such, we sho...

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Detalhes bibliográficos
Main Authors: Mellanby, Richard J, Cambrook, Helen, Turner, Darryl G, O’Connor, Richard A, Leech, Melanie D, Kurschus, Florian C, MacDonald, Andrew S, Arnold, Bernd, Anderton, Stephen M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520704/
https://ncbi.nlm.nih.gov/pubmed/23111144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-248
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