PD‐1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state

T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell population can respond effectively to pathogens but remains tolerant to self‐antigens. We probed the mechanisms of T cell adaptation using an experimental autoimmune encephalomyelitis (EAE) model in which...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Mair, Iris, Besusso, Dario, Saul, Louise, Patel, Sarju D., Ravindran, Rahul, McPherson, Rhoanne C., Leech, Melanie D., O'Connor, Richard A., Anderton, Stephen M., Mellanby, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Adaptive immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492152/
https://ncbi.nlm.nih.gov/pubmed/30485411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201847868
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