Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (T(CD8)). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activati...

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Hauptverfasser: Tewalt, Eric F., Cohen, Jarish N., Rouhani, Sherin J., Guidi, Cynthia J., Qiao, Hui, Fahl, Shawn P., Conaway, Mark R., Bender, Timothy P., Tung, Kenneth S., Vella, Anthony T., Adler, Adam J., Chen, Lieping, Engelhard, Victor H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520619/
https://ncbi.nlm.nih.gov/pubmed/22993390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-427013
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