Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment

Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic endothelial cells in mice directly express peripheral tissue antigens, including tyrosinase, and induce deletion of specific CD8 T cells via...

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Main Authors: Cohen, Jarish N., Tewalt, Eric F., Rouhani, Sherin J., Buonomo, Erica L., Bruce, Amber N., Xu, Xiaojiang, Bekiranov, Stefan, Fu, Yang-Xin, Engelhard, Victor H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913631/
https://ncbi.nlm.nih.gov/pubmed/24503860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087740
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