Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules, suggesting they might also tolerize CD4 T cells. We demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Rouhani, Sherin J., Eccles, Jacob D., Riccardi, Priscila, Peske, J. David, Tewalt, Eric F., Cohen, Jarish N., Liblau, Roland, Mäkinen, Taija, Engelhard, Victor H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403767/
https://ncbi.nlm.nih.gov/pubmed/25857745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7771
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