Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (T(CD8)). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activati...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Tewalt, Eric F., Cohen, Jarish N., Rouhani, Sherin J., Guidi, Cynthia J., Qiao, Hui, Fahl, Shawn P., Conaway, Mark R., Bender, Timothy P., Tung, Kenneth S., Vella, Anthony T., Adler, Adam J., Chen, Lieping, Engelhard, Victor H.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520619/
https://ncbi.nlm.nih.gov/pubmed/22993390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-427013
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires