Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (T(CD8)). We demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1, despite expressing ligands for the CD160, B- and T-lymphocyte attenuator, and lymphocyte activati...

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保存先:
書誌詳細
主要な著者: Tewalt, Eric F., Cohen, Jarish N., Rouhani, Sherin J., Guidi, Cynthia J., Qiao, Hui, Fahl, Shawn P., Conaway, Mark R., Bender, Timothy P., Tung, Kenneth S., Vella, Anthony T., Adler, Adam J., Chen, Lieping, Engelhard, Victor H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2012
主題:
Immunobiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3520619/
https://ncbi.nlm.nih.gov/pubmed/22993390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-427013
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