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Dual roles of PARP-1 promote cancer growth and progression

Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair, and also functions as a context-specific regulator of transcription factors. Using multiple models, data demonstrate th...

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主要な著者: Schiewer, Matthew J., Goodwin, Jonathan F., Han, Sumin, Brenner, J. Chad, Augello, Michael A., Dean, Jeffry L., Liu, Fengzhi, Planck, Jamie L., Ravindranathan, Preethi, Chinnaiyan, Arul M., McCue, Peter, Gomella, Leonard G., Raj, Ganesh V., Dicker, Adam P., Brody, Jonathan R., Pascal, John M., Centenera, Margaret M., Butler, Lisa M., Tilley, Wayne D., Feng, Felix Y., Knudsen, Karen E.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519969/
https://ncbi.nlm.nih.gov/pubmed/22993403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0120
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