Dual roles of PARP-1 promote cancer growth and progression

Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair, and also functions as a context-specific regulator of transcription factors. Using multiple models, data demonstrate th...

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Detalhes bibliográficos
Main Authors: Schiewer, Matthew J., Goodwin, Jonathan F., Han, Sumin, Brenner, J. Chad, Augello, Michael A., Dean, Jeffry L., Liu, Fengzhi, Planck, Jamie L., Ravindranathan, Preethi, Chinnaiyan, Arul M., McCue, Peter, Gomella, Leonard G., Raj, Ganesh V., Dicker, Adam P., Brody, Jonathan R., Pascal, John M., Centenera, Margaret M., Butler, Lisa M., Tilley, Wayne D., Feng, Felix Y., Knudsen, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519969/
https://ncbi.nlm.nih.gov/pubmed/22993403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0120
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