Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers

BACKGROUND: While BRCA mutation carriers possess a 20-40% lifetime risk of developing ovarian cancer, knowledge about genetic modifying factors influencing the phenotypic expression remains obscure. We explored the distribution of the MDM2 polymorphisms SNP309T>G and the recently discovered SNP28...

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Main Authors: Bjørnslett, Merete, Knappskog, Stian, Lønning, Per Eystein, Dørum, Anne
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519699/
https://ncbi.nlm.nih.gov/pubmed/23039163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-454
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