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Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk
The proto-oncogene MDM2 inhibits p53 and plays a key role in cell growth control and apoptosis. Identification of two antagonizing MDM2 polymorphisms, SNP285 and SNP309, affecting cancer risk through modulation of Sp1 transcription factor binding, shed new light on the biological activity and phylog...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Landes Bioscience
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3265776/ https://ncbi.nlm.nih.gov/pubmed/22231115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.2.5.16813 |
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