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Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk

The proto-oncogene MDM2 inhibits p53 and plays a key role in cell growth control and apoptosis. Identification of two antagonizing MDM2 polymorphisms, SNP285 and SNP309, affecting cancer risk through modulation of Sp1 transcription factor binding, shed new light on the biological activity and phylog...

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Bibliographic Details
Main Authors: Knappskog, Stian, Lønning, Per E
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265776/
https://ncbi.nlm.nih.gov/pubmed/22231115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/trns.2.5.16813
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