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Atomistic Mechanism for the Activation and Desensitization of an AMPA-Subtype Glutamate Receptor
Ionotropic glutamate receptors (iGluRs) mediate fast excitatory synaptic transmission in the central nervous system. Upon agonist binding, an iGluR opens to allow the flow of cations and subsequently enters into a desensitized state. It remains unclear how agonist binding to the ligand-binding domai...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518439/ https://ncbi.nlm.nih.gov/pubmed/21673675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1362 |
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