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Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl(−) secretion by human autosomal dominant polycystic kidney cells
In autosomal dominant polycystic kidney disease (ADPKD), binding of AVP to the V2 receptor (V2R) increases cAMP and accelerates cyst growth by stimulating cell proliferation and Cl(−)-dependent fluid secretion. Basal cAMP is elevated in human ADPKD cells compared with normal human kidney (NHK) cells...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517630/ https://ncbi.nlm.nih.gov/pubmed/22952279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00692.2011 |
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