Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl(−) secretion by human autosomal dominant polycystic kidney cells

In autosomal dominant polycystic kidney disease (ADPKD), binding of AVP to the V2 receptor (V2R) increases cAMP and accelerates cyst growth by stimulating cell proliferation and Cl(−)-dependent fluid secretion. Basal cAMP is elevated in human ADPKD cells compared with normal human kidney (NHK) cells...

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Main Authors: Pinto, Cibele S., Reif, Gail A., Nivens, Emily, White, Corey, Wallace, Darren P.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517630/
https://ncbi.nlm.nih.gov/pubmed/22952279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00692.2011
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