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Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases

Since small molecule activators of adenylyl cyclases (AC) impact ACs cell-wide, it is challenging the explore the signaling consequences of AC activity emanating from specific intracellular compartments. We explored this issue using a series of engineered, optogenetic, spatially-restricted, photoact...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Chem Biol
Prif Awduron: O’Banion, Colin P., Vickerman, Brianna M., Haar, Lauren, Lawrence, David S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800631/
https://ncbi.nlm.nih.gov/pubmed/31353320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.004
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