Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases

Since small molecule activators of adenylyl cyclases (AC) impact ACs cell-wide, it is challenging the explore the signaling consequences of AC activity emanating from specific intracellular compartments. We explored this issue using a series of engineered, optogenetic, spatially-restricted, photoact...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Chem Biol
Main Authors: O’Banion, Colin P., Vickerman, Brianna M., Haar, Lauren, Lawrence, David S.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800631/
https://ncbi.nlm.nih.gov/pubmed/31353320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.004
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