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Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease
cAMP stimulates cell proliferation and Cl(–)-dependent fluid secretion, promoting the progressive enlargement of renal cysts in autosomal dominant polycystic kidney disease (ADPKD). Intracellular cAMP levels are determined by the balance of cAMP synthesis by adenylyl cyclases and degradation by phos...
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| Publicado no: | J Am Soc Nephrol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4814181/ https://ncbi.nlm.nih.gov/pubmed/26289612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015010047 |
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