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A Tumor Necrosis Factor-Alpha-Mediated Pathway Promoting Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is caused by heterozygous mutations in either PKD1 or PKD2, genes that encode polycystin (PC) -1 and -2, respectively (1). We show here that tumor necrosis factor-alpha (TNF-α), an inflammatory cytokine present in human ADPKD cystic fluid, disrupt...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3359869/ https://ncbi.nlm.nih.gov/pubmed/18552856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1783 |
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