A Tumor Necrosis Factor-Alpha-Mediated Pathway Promoting Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) is caused by heterozygous mutations in either PKD1 or PKD2, genes that encode polycystin (PC) -1 and -2, respectively (1). We show here that tumor necrosis factor-alpha (TNF-α), an inflammatory cytokine present in human ADPKD cystic fluid, disrupt...

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Main Authors: Li, Xiaogang, Magenheimer, Brenda S., Xia, Sheng, Johnson, Teri, Wallace, Darren P., Calvet, James P., Li, Rong
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359869/
https://ncbi.nlm.nih.gov/pubmed/18552856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1783
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