Fast, Cell-compatible Click Chemistry with Copper-chelating Azides for Biomolecular Labeling

[Image: see text] We report that azides capable of copper-chelation undergo much faster “Click chemistry” (copper-accelerated azide-alkyne cycloaddition, or CuAAC) than nonchelating azides under a variety of biocompatible conditions. This kinetic enhancement allowed us to perform site-specific prote...

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Detalhes bibliográficos
Main Authors: Uttamapinant, Chayasith, Tangpeerachaikul, Anupong, Grecian, Scott, Clarke, Scott, Singh, Upinder, Slade, Peter, Gee, Kyle R., Ting, Alice. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517120/
https://ncbi.nlm.nih.gov/pubmed/22555882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201108181
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