Improved synthesis and biological evaluation of chelator-modified α-MSH analogues prepared by copper-free click chemistry

Radionuclide chelators (DOTA, NOTA) functionalized with a monofluorocyclooctyne group were prepared. These materials reacted rapidly and in high yield with a fully deprotected azide-modified peptide via Cu-free click chemistry under mild reaction conditions (aqueous solution, room temperature). The...

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Main Authors: Baumhover, Nicholas J., Martin, Molly E., Parameswarappa, Sharavathi G., Kloepping, Kyle C., O’Dorisio, M. Sue, Pigge, F. Christopher, Schultz, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171621/
https://ncbi.nlm.nih.gov/pubmed/21873053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.08.017
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