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Improved synthesis and biological evaluation of chelator-modified α-MSH analogues prepared by copper-free click chemistry
Radionuclide chelators (DOTA, NOTA) functionalized with a monofluorocyclooctyne group were prepared. These materials reacted rapidly and in high yield with a fully deprotected azide-modified peptide via Cu-free click chemistry under mild reaction conditions (aqueous solution, room temperature). The...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3171621/ https://ncbi.nlm.nih.gov/pubmed/21873053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.08.017 |
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