DOCK8 is essential for T-cell survival and the maintenance of CD8(+) T-cell memory

Deficiency in the guanine nucleotide exchange factor DOCK8 causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and viral infections. We have recently identified a DOCK8-deficient mouse strain, carrying an ethylnitrosourea-induced splice-site mutation that shows a failure...

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Main Authors: Lambe, Teresa, Crawford, Greg, Johnson, Andy L., Crockford, Tanya L., Bouriez-Jones, Tiphaine, Smyth, Aisling M., Pham, Trung H.M., Zhang, Qian, Freeman, Alexandra F., Cyster, Jason G., Su, Helen C., Cornall, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517112/
https://ncbi.nlm.nih.gov/pubmed/21969276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141759
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