Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

Ceramide synthase 1 (CerS1) catalyzes the synthesis of C18 ceramide and is mainly expressed in the brain. Custom-made antibodies to a peptide from the C-terminal region of the mouse CerS1 protein yielded specific immunosignals in neurons but no other cell types of wild type brain, but the CerS1 prot...

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Main Authors: Ginkel, Christina, Hartmann, Dieter, vom Dorp, Katharina, Zlomuzica, Armin, Farwanah, Hany, Eckhardt, Matthias, Sandhoff, Roger, Degen, Joachim, Rabionet, Mariona, Dere, Ekrem, Dörmann, Peter, Sandhoff, Konrad, Willecke, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516736/
https://ncbi.nlm.nih.gov/pubmed/23074226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.413500
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