Ligand Directed Signaling Differences between Rodent and Human κ-Opioid Receptors

KOR activation of Gβγ dependent signaling results in analgesia, whereas the dysphoric effects of KOR agonists are mediated by a different pathway involving G protein receptor kinase and non-visual arrestin. Based on this distinction, a partial KOR agonist that does not efficiently activate arrestin-...

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Bibliographic Details
Main Authors: Schattauer, Selena S., Miyatake, Mayumi, Shankar, Haripriya, Zietz, Chad, Levin, Jamie R., Liu-Chen, Lee-Yuan, Gurevich, Vsevolod V., Rieder, Mark J., Chavkin, Charles
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516711/
https://ncbi.nlm.nih.gov/pubmed/23086943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.381368
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