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Tyrosine Phosphorylation of K(ir)3 following κ-Opioid Receptor Activation of p38 MAPK Causes Heterologous Desensitization

Prior studies showed that tyrosine 12 phosphorylation in the N-terminal, cytoplasmic domain of the G-protein-gated inwardly rectifying potassium channel, K(ir)3.1 facilitates channel deactivation by increasing intrinsic GTPase activity of the channel. Using a phosphoselective antibody directed again...

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Bibliografski detalji
Glavni autori: Clayton, Cecilea C., Xu, Mei, Chavkin, Charles
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797258/
https://ncbi.nlm.nih.gov/pubmed/19773548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053793
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