Integrative Analysis of a Cross-Loci Regulation Network Identifies App as a Gene Regulating Insulin Secretion from Pancreatic Islets

Complex diseases result from molecular changes induced by multiple genetic factors and the environment. To derive a systems view of how genetic loci interact in the context of tissue-specific molecular networks, we constructed an F2 intercross comprised of >500 mice from diabetes-resistant (B6) a...

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Autori principali: Tu, Zhidong, Keller, Mark P., Zhang, Chunsheng, Rabaglia, Mary E., Greenawalt, Danielle M., Yang, Xia, Wang, I-Ming, Dai, Hongyue, Bruss, Matthew D., Lum, Pek Y., Zhou, Yun-Ping, Kemp, Daniel M., Kendziorski, Christina, Yandell, Brian S., Attie, Alan D., Schadt, Eric E., Zhu, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516550/
https://ncbi.nlm.nih.gov/pubmed/23236292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003107
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