A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication betwe...

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Main Authors: Keller, Mark P., Choi, YounJeong, Wang, Ping, Belt Davis, Dawn, Rabaglia, Mary E., Oler, Angie T., Stapleton, Donald S., Argmann, Carmen, Schueler, Kathy L., Edwards, Steve, Steinberg, H. Adam, Chaibub Neto, Elias, Kleinhanz, Robert, Turner, Scott, Hellerstein, Marc K., Schadt, Eric E., Yandell, Brian S., Kendziorski, Christina, Attie, Alan D.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2008
Teme:
Letter
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2336811/
https://ncbi.nlm.nih.gov/pubmed/18347327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.074914.107
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