UGT1A1 predicts outcome in colorectal cancer treated with irinotecan and fluorouracil

AIM: To evaluate effects of UDP-glucuronosyltransferase1A1 (UGT1A1) and thymidylate synthetase (TS) gene polymorphisms on irinotecan in metastatic colorectal cancer (mCRC). METHODS: Two irinotecan- and fluorouracil-based regimens, FOLFIRI and IFL, were selected as second-line therapy for 138 Chinese...

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Autores principales: Wang, Yan, Shen, Lin, Xu, Nong, Wang, Jin-Wan, Jiao, Shun-Chang, Liu, Ze-Yuan, Xu, Jian-Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Baishideng Publishing Group Co., Limited 2012
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Brief Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516223/
https://ncbi.nlm.nih.gov/pubmed/23236239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v18.i45.6635
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