Refining the UGT1A Haplotype Associated with Irinotecan-Induced Hematological Toxicity in Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Irinotecan-Based Regimens

Despite the importance of UDP-glucuronosyltransferase (UGT) 1A1*28 in irinotecan pharmacogenetics, our capability to predict drug-induced severe toxicity remains limited. We aimed at identifying novel genetic markers that would improve prediction of irinotecan toxicity and response in advanced color...

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Main Authors: Lévesque, Éric, Bélanger, Anne-Sophie, Harvey, Mario, Couture, Félix, Jonker, Derek, Innocenti, Federico, Cecchin, Erica, Toffoli, Giuseppe, Guillemette, Chantal
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2013
Teme:
Metabolism, Transport, and Pharmacogenomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920089/
https://ncbi.nlm.nih.gov/pubmed/23386248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.202242
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