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Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells
BACKGROUND: UDP-glucuronosyltransferase 1A1 (UGT1A1) is a pivotal enzyme involved in metabolism of SN-38, the active metabolite of irinotecan commonly used to treat metastatic colorectal cancer. We previously demonstrated aberrant methylation of specific CpG dinucleotides in UGT1A1-negative cells, a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835698/ https://ncbi.nlm.nih.gov/pubmed/20096102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-9 |
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