Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine

The non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is directly conjugated by the UDP-glucuronosyltransferase (UGT) pathway to form EFV-N-glucuronide (EFV-G), but the enzyme(s) involved has not yet been identified. The glucuronidation of EFV was screened with UGT1A and UGT2B enzymes e...

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Bibliographic Details
Main Authors: Bélanger, Anne-Sophie, Caron, Patrick, Harvey, Mario, Zimmerman, Peter A., Mehlotra, Rajeev K., Guillemette, Chantal
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
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Short Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729325/
https://ncbi.nlm.nih.gov/pubmed/19487252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.027706
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