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The Human UGT1A3 Enzyme Conjugates Norursodeoxycholic Acid into a C(23)-ester Glucuronide in the Liver
Norursodeoxycholic acid (norUDCA) exhibits efficient anti-cholestatic properties in an animal model of sclerosing cholangitis. norUDCA is eliminated as a C(23)-ester glucuronide (norUDCA-23G) in humans. The present study aimed at identifying the human UDP-glucuronosyltransferase (UGT) enzyme(s) invo...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801239/ https://ncbi.nlm.nih.gov/pubmed/19889628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073908 |
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