The Human UGT1A3 Enzyme Conjugates Norursodeoxycholic Acid into a C(23)-ester Glucuronide in the Liver

Norursodeoxycholic acid (norUDCA) exhibits efficient anti-cholestatic properties in an animal model of sclerosing cholangitis. norUDCA is eliminated as a C(23)-ester glucuronide (norUDCA-23G) in humans. The present study aimed at identifying the human UDP-glucuronosyltransferase (UGT) enzyme(s) invo...

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Detalhes bibliográficos
Main Authors: Trottier, Jocelyn, El Husseini, Diala, Perreault, Martin, Pâquet, Sophie, Caron, Patrick, Bourassa, Sylvie, Verreault, Mélanie, Inaba, Ted T., Poirier, Guy G., Bélanger, Alain, Guillemette, Chantal, Trauner, Michael, Barbier, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801239/
https://ncbi.nlm.nih.gov/pubmed/19889628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.073908
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