Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions

Biliary obstruction, a severe cholestatic complication, causes accumulation of toxic bile acids (BAs) in liver cells. Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic BAs. Using liquid chromatography coupled to tandem mass spectrometry, 11 BA glucuronid...

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Publicado en:Can J Gastroenterol Hepatol
Autores principales: Perreault, Martin, Wunsch, Ewa, Białek, Andrzej, Trottier, Jocelyn, Verreault, Mélanie, Caron, Patrick, Poirier, Guy G., Milkiewicz, Piotr, Barbier, Olivier
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925157/
https://ncbi.nlm.nih.gov/pubmed/29850459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8096314
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